Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC057
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-12-15 15:01
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment madopar 3x1\4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 5 individuals with a value less than 0.52 were subsequently diagnosed with PD. That is, 11.9% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.52 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 11, 'TN': 10, 'TP': 31, 'FP': 20}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 17, 'TN': 12, 'TP': 25, 'FP': 18}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 7, 'TN': 7, 'TP': 35, 'FP': 23}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 3, 'TN': 3, 'TP': 39, 'FP': 27}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 4.912
timePerCircleCoV 0.169769
timePerCircleSlope -0.0465897
meanError 2.93187
tremorFreq 7.61719
tremorRelPower 35.7329
tremorGyroAmpMean 0.0506094
tremorGyroAmpSlope 0.00101667
tremorGyroAmpCoV 0.368204
tremorCoordAmpMean 0.0912966
tremorCoordAmpSlope -0.00151127
tremorCoordAmpCoV 0.355629
tremorAccAmpMean 0.0770341
tremorAccAmpSlope 0.00130855
tremorAccAmpCoV 0.257904
tremorPcRelVar 0.657054
tremorPcX 0.885586
tremorPcY 0.464475

Circle Segment 1

Duration 5.88 s, Accuracy Estimate 3.336 (lower is better)

Circle Segment 2

Duration 5.72 s, Accuracy Estimate 2.923 (lower is better)

Circle Segment 3

Duration 5.76 s, Accuracy Estimate 3.848 (lower is better)

Circle Segment 4

Duration 4.2 s, Accuracy Estimate 2.098 (lower is better)

Circle Segment 5

Duration 5.68 s, Accuracy Estimate 2.808 (lower is better)

Circle Segment 6

Duration 4.92 s, Accuracy Estimate 2.847 (lower is better)

Circle Segment 7

Duration 4.92 s, Accuracy Estimate 2.629 (lower is better)

Circle Segment 8

Duration 4.32 s, Accuracy Estimate 1.794 (lower is better)

Circle Segment 9

Duration 4.24 s, Accuracy Estimate 3.511 (lower is better)

Circle Segment 10

Duration 3.48 s, Accuracy Estimate 3.524 (lower is better)

Spiral

numSpirals 10
timePerSpiralMean 16.18
timePerSpiralCoV 0.0501968
timePerSpiralSlope 0.00519909
meanError 2.4577
tremorFreq 7.32422
tremorRelPower 41.4386
tremorGyroAmpMean 0.064451
tremorGyroAmpSlope 0.000272779
tremorGyroAmpCoV 0.350679
tremorCoordAmpMean 0.108111
tremorCoordAmpSlope 0.000190283
tremorCoordAmpCoV 0.367283
tremorAccAmpMean 0.0808705
tremorAccAmpSlope 0.000344136
tremorAccAmpCoV 0.371572
tremorPcRelVar 0.690839
tremorPcX -0.983946
tremorPcY -0.178469

Spiral Segment 1

Duration 17.28 s, Accuracy Estimate 1.978 (lower is better)

Spiral Segment 2

Duration 15.24 s, Accuracy Estimate 2.35 (lower is better)

Spiral Segment 3

Duration 16.08 s, Accuracy Estimate 2.869 (lower is better)

Spiral Segment 4

Duration 15.08 s, Accuracy Estimate 2.564 (lower is better)

Spiral Segment 5

Duration 16.32 s, Accuracy Estimate 2.353 (lower is better)

Spiral Segment 6

Duration 15.52 s, Accuracy Estimate 2.337 (lower is better)

Spiral Segment 7

Duration 15.52 s, Accuracy Estimate 2.457 (lower is better)

Spiral Segment 8

Duration 16.68 s, Accuracy Estimate 2.706 (lower is better)

Spiral Segment 9

Duration 17.08 s, Accuracy Estimate 2.226 (lower is better)

Spiral Segment 10

Duration 17.0 s, Accuracy Estimate 2.737 (lower is better)

Elel

eDurationMean 0.355638
eDurationStd 0.0793151
eDurationStdnorm 0.223022
eDurationMedian 0.335
eDurationQuartdelta 0.0825
eDurationQuartdeltanorm 0.246269
eDurationKurt 8.55066
eDurationTrenddiff -0.045
eDurationTrendratio 0.873239
eWidthMean 12.0908
eWidthStd 3.61568
eWidthStdnorm 0.299043
eWidthMedian 11.232
eWidthQuartdelta 5.967
eWidthQuartdeltanorm 0.53125
eWidthKurt 1.95072
eWidthTrenddiff 5.967
eWidthTrendratio 1.65385
eHeightMean 18.0553
eHeightStd 2.86041
eHeightStdnorm 0.158424
eHeightMedian 17.784
eHeightQuartdelta 3.59775
eHeightQuartdeltanorm 0.202303
eHeightKurt 2.8494
eHeightTrenddiff 2.691
eHeightTrendratio 1.16197
eAspectMean 0.662431
eAspectStd 0.138567
eAspectStdnorm 0.20918
eAspectMedian 0.641618
eAspectQuartdelta 0.169955
eAspectQuartdeltanorm 0.264885
eAspectKurt 3.62463
eAspectTrenddiff 0.136314
eAspectTrendratio 1.23224
eSlantMean 0.480444
eSlantStd 0.149305
eSlantStdnorm 0.310764
eSlantMedian 0.485714
eSlantQuartdelta 0.185624
eSlantQuartdeltanorm 0.382167
eSlantKurt 2.86205
eSlantTrenddiff 0.147316
eRtopMean 0.951876
eRtopStd 0.0355592
eRtopStdnorm 0.0373569
eRtopMedian 0.965116
eRtopQuartdelta 0.0506234
eRtopQuartdeltanorm 0.0524531
eRtopKurt 3.28031
eRtopTrenddiff 0.0395764
eRbotMean 0.240186
eRbotStd 0.112457
eRbotStdnorm 0.468208
eRbotMedian 0.20155
eRbotQuartdelta 0.158055
eRbotQuartdeltanorm 0.784196
eRbotKurt 3.08872
eRbotTrenddiff -0.0421053
eRrightMean 0.962079
eRrightStd 0.0319871
eRrightStdnorm 0.0332479
eRrightMedian 0.971098
eRrightQuartdelta 0.0438281
eRrightQuartdeltanorm 0.0451325
eRrightKurt 4.29913
eRrightTrenddiff 0.026217
eRleftMean 0.134113
eRleftStd 0.0506123
eRleftStdnorm 0.377385
eRleftMedian 0.121951
eRleftQuartdelta 0.0662838
eRleftQuartdeltanorm 0.543527
eRleftKurt 4.2502
eRleftTrenddiff -0.0382636
lDurationMean 0.43725
lDurationStd 0.0875298
lDurationStdnorm 0.200183
lDurationMedian 0.435
lDurationQuartdelta 0.0925
lDurationQuartdeltanorm 0.212644
lDurationKurt 7.61359
lDurationTrenddiff -0.0875
lDurationTrendratio 0.810811
lWidthMean 18.5913
lWidthStd 4.04848
lWidthStdnorm 0.217762
lWidthMedian 18.486
lWidthQuartdelta 6.318
lWidthQuartdeltanorm 0.341772
lWidthKurt 2.6259
lWidthTrenddiff 6.2595
lWidthTrendratio 1.4084
lHeightMean 30.5194
lHeightStd 4.40472
lHeightStdnorm 0.144325
lHeightMedian 30.186
lHeightQuartdelta 6.435
lHeightQuartdeltanorm 0.213178
lHeightKurt 2.57625
lHeightTrenddiff 2.808
lHeightTrendratio 1.09776
lAspectMean 0.608847
lAspectStd 0.102351
lAspectStdnorm 0.168106
lAspectMedian 0.616077
lAspectQuartdelta 0.159427
lAspectQuartdeltanorm 0.258778
lAspectKurt 2.54171
lAspectTrenddiff 0.146941
lAspectTrendratio 1.27111
lSlantMean 0.460789
lSlantStd 0.111461
lSlantStdnorm 0.241892
lSlantMedian 0.453163
lSlantQuartdelta 0.179347
lSlantQuartdeltanorm 0.395766
lSlantKurt 2.66538
lSlantTrenddiff 0.179347
lRtopMean 0.95434
lRtopStd 0.0403788
lRtopStdnorm 0.0423107
lRtopMedian 0.967947
lRtopQuartdelta 0.0412912
lRtopQuartdeltanorm 0.0426586
lRtopKurt 3.64586
lRtopTrenddiff -0.000698411
lRbotMean 0.205665
lRbotStd 0.0597423
lRbotStdnorm 0.290484
lRbotMedian 0.198054
lRbotQuartdelta 0.0753356
lRbotQuartdeltanorm 0.380379
lRbotKurt 3.54223
lRbotTrenddiff -0.0575406
lRrightMean 0.96437
lRrightStd 0.0290281
lRrightStdnorm 0.0301006
lRrightMedian 0.967777
lRrightQuartdelta 0.0409042
lRrightQuartdeltanorm 0.0422661
lRrightKurt 4.93237
lRrightTrenddiff 0.0196766
lRleftMean 0.135455
lRleftStd 0.0506983
lRleftStdnorm 0.37428
lRleftMedian 0.123742
lRleftQuartdelta 0.0507515
lRleftQuartdeltanorm 0.41014
lRleftKurt 8.44151
lRleftTrenddiff -0.0314371

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

FITTS Short Modified

meanTouchScore 0.912186
sumTouchScores 18.2437
meanMovementTime 0.742895
numTouches 20
undershootPercentage 0
overshootPercentage 15

FITTS Long Modified

meanTouchScore 0.796917
sumTouchScores 17.5322
meanMovementTime 0.843571
numTouches 22
undershootPercentage 4.54545
overshootPercentage 13.6364

ZigZag

numZigzags 5
timePerZigzagMean 12.52
timePerZigzagCoV 0.0769099
timePerZigzagSlope -0.0121406
meanError 2.90094
tremorFreq 7.22656
tremorRelPower 36.6554
tremorGyroAmpMean 0.0641884
tremorGyroAmpSlope 0.00308047
tremorGyroAmpCoV 0.360153
tremorCoordAmpMean 0.102897
tremorCoordAmpSlope 0.00116314
tremorCoordAmpCoV 0.397664
tremorAccAmpMean 0.067156
tremorAccAmpSlope 0.00150406
tremorAccAmpCoV 0.469347
tremorPcRelVar 0.602115
tremorPcX -0.975685
tremorPcY 0.219178

ZigZag Segment 1

Duration 13.92 s, Accuracy Estimate 3.38 (lower is better)

ZigZag Segment 2

Duration 11.72 s, Accuracy Estimate 3.116 (lower is better)

ZigZag Segment 3

Duration 12.04 s, Accuracy Estimate 2.721 (lower is better)

ZigZag Segment 4

Duration 11.8 s, Accuracy Estimate 2.41 (lower is better)

ZigZag Segment 5

Duration 13.12 s, Accuracy Estimate 2.877 (lower is better)

ZigZag Offset

numZigzags 5
timePerZigzagMean 11.088
timePerZigzagCoV 0.245567
timePerZigzagSlope -0.13961
zigzagHeightMean 65.7782
zigzagHeightCoV 0.0155474
zigzagHeightSlope 0.00069788
meanError 0.0544271
tremorFreq 7.61719
tremorRelPower 34.0483
tremorGyroAmpMean 0.0932416
tremorGyroAmpSlope 0.00625968
tremorGyroAmpCoV 0.297716
tremorCoordAmpMean 0.155204
tremorCoordAmpSlope 0.00420324
tremorCoordAmpCoV 0.310625
tremorAccAmpMean 0.123455
tremorAccAmpSlope 0.00169165
tremorAccAmpCoV 0.288207
tremorPcRelVar 0.792475
tremorPcX -0.758199
tremorPcY 0.652023

ZigZag Offset Segment 1

Duration 15.68 s, Accuracy Estimate 0.065 (lower is better)

ZigZag Offset Segment 2

Duration 11.12 s, Accuracy Estimate 0.045 (lower is better)

ZigZag Offset Segment 3

Duration 10.24 s, Accuracy Estimate 0.048 (lower is better)

ZigZag Offset Segment 4

Duration 9.8 s, Accuracy Estimate 0.041 (lower is better)

ZigZag Offset Segment 5

Duration 8.6 s, Accuracy Estimate 0.073 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.86}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.52}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.7693664752601403}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.9172546018376833}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘nonPD’, ‘BM_PD_Sep22_score’: 0.44262119039553416}